| Week | Date ▲ | Day | Favorite | Spread | Underdog |
|---|
| 1 | 2025-08-28 | Thursday | Rutgers | 15 | Ohio |
| 1 | 2025-08-28 | Thursday | Wyoming | 7 | Akron |
| 1 | 2025-08-28 | Thursday | Nebraska | 7 | Cincinnati |
| 1 | 2025-08-28 | Thursday | North Carolina State | 13 | East Carolina |
| 1 | 2025-08-28 | Thursday | UCF | 19 | Jacksonville State |
| 1 | 2025-08-28 | Thursday | Boise State | 6.5 | South Florida |
| 1 | 2025-08-28 | Thursday | San Diego State | 19.5 | Stony Brook |
| 1 | 2025-08-29 | Friday | Wake Forest | 18 | Kennesaw State |
| 1 | 2025-08-29 | Friday | Illinois | 45.5 | Western Illinois |
| 1 | 2025-08-29 | Friday | Michigan State | 20.5 | Western Michigan |
| 1 | 2025-08-29 | Friday | UNLV | 10.5 | Sam Houston |
| 1 | 2025-08-29 | Friday | Auburn | 2.5 | Baylor |
| 1 | 2025-08-29 | Friday | San Jose State | 12.5 | Central Michigan |
| 1 | 2025-08-29 | Friday | Appalachian State | 6.5 | Charlotte |
| 1 | 2025-08-29 | Friday | Georgia Tech | 5 | Colorado |
| 1 | 2025-08-30 | Saturday | Iowa State | 14.5 | South Dakota |
| 1 | 2025-08-30 | Saturday | Texas A&M | 24.5 | UTSA |
| 1 | 2025-08-30 | Saturday | Temple | 2.5 | UMass |
| 1 | 2025-08-30 | Saturday | Georgia Southern | 1.5 | Fresno State |
| 1 | 2025-08-30 | Saturday | Alabama | 13.5 | Florida State |
| 1 | 2025-08-30 | Saturday | Arkansas State | 10.5 | Southeast Missouri State |
| 1 | 2025-08-30 | Saturday | Ohio State | 1.5 | Texas |
| 1 | 2025-08-30 | Saturday | Liberty | 25.5 | Maine |
| 1 | 2025-08-30 | Saturday | Arizona State | 28.5 | Northern Arizona |
| 1 | 2025-08-30 | Saturday | Tulane | 6 | Northwestern |
| 1 | 2025-08-30 | Saturday | Oregon | 27.5 | Montana State |
| 1 | 2025-08-30 | Saturday | USC | 35 | Missouri State |
| 1 | 2025-08-30 | Saturday | Washington State | 13.5 | Idaho |
| 1 | 2025-08-30 | Saturday | Michigan | 35 | New Mexico |
| 1 | 2025-08-30 | Saturday | Louisiana Tech | 12.5 | Southeastern Louisiana |
| 1 | 2025-08-30 | Saturday | Oregon State | 2 | California |
| 1 | 2025-08-30 | Saturday | Clemson | 4 | LSU |
| 1 | 2025-08-30 | Saturday | Arizona | 17.5 | Hawaii |
| 1 | 2025-08-30 | Saturday | Washington | 22.5 | Colorado State |
| 1 | 2025-08-30 | Saturday | Utah | 6 | UCLA |
| 1 | 2025-08-30 | Saturday | Maryland | 14.5 | Florida Atlantic |
| 1 | 2025-08-30 | Saturday | Virginia | 12 | Coastal Carolina |
| 1 | 2025-08-30 | Saturday | Utah State | 6 | UTEP |
| 1 | 2025-08-30 | Saturday | Oklahoma | 35 | Illinois State |
| 1 | 2025-08-30 | Saturday | Ole Miss | 36 | Georgia State |
| 1 | 2025-08-30 | Saturday | Iowa | 37.5 | University at Albany |
| 1 | 2025-08-30 | Saturday | Louisiana | 11.5 | Rice |
| 1 | 2025-08-30 | Saturday | Texas State | 14 | Eastern Michigan |
| 1 | 2025-08-30 | Saturday | Purdue | 17.5 | Ball State |
| 1 | 2025-08-30 | Saturday | BYU | 43.5 | Portland State |
| 1 | 2025-08-30 | Saturday | James Madison | 25.5 | Weber State |
| 1 | 2025-08-30 | Saturday | Mississippi State | 13.5 | Southern Miss |
| 1 | 2025-08-30 | Saturday | New Mexico State | 20 | Bryant |
| 1 | 2025-08-30 | Saturday | Tennessee | 13.5 | Syracuse |
| 1 | 2025-08-30 | Saturday | Troy | 20.5 | Nicholls State |
| 1 | 2025-08-30 | Saturday | Kentucky | 7.5 | Toledo |
| 1 | 2025-08-30 | Saturday | Indiana | 24 | Old Dominion |
| 1 | 2025-08-30 | Saturday | Kansas State | 25.5 | North Dakota |
| 1 | 2025-08-30 | Saturday | Penn State | 44 | Nevada |
| 1 | 2025-08-30 | Saturday | Georgia | 39.5 | Marshall |
| 1 | 2025-08-30 | Saturday | Vanderbilt | 37 | Charleston Southern |
| 2 | 2025-09-05 | Friday | Louisville | 14.5 | James Madison |
| 2 | 2025-09-05 | Friday | Maryland | 18.5 | Northern Illinois |
| 2 | 2025-09-06 | Saturday | Penn State | 41.5 | Florida International |
| 2 | 2025-09-06 | Saturday | Texas | 36.5 | San Jose State |
| 2 | 2025-09-06 | Saturday | SMU | 2.5 | Baylor |
| 2 | 2025-09-06 | Saturday | Iowa State | 3.5 | Iowa |
| 2 | 2025-09-06 | Saturday | Illonois | 2.5 | Duke |
| 2 | 2025-09-06 | Saturday | Oregon State | 3.5 | Fresno State |
| 2 | 2025-09-06 | Saturday | Ole Miss | 10.5 | Kentucky |
| 2 | 2025-09-06 | Saturday | Oregon | 28.5 | Oklahoma State |
| 2 | 2025-09-06 | Saturday | Clemson | 33.5 | Troy |
| 2 | 2025-09-06 | Saturday | Missouri | 6.5 | Kansas |
| 2 | 2025-09-06 | Saturday | Florida | 17.5 | South Florida |
| 2 | 2025-09-06 | Saturday | Kansas State | 17.5 | Army |
| 2 | 2025-09-06 | Saturday | Washington State | 1.5 | San Diego State |
| 2 | 2025-09-06 | Saturday | BYU | 18.5 | Stanford |
| 2 | 2025-09-06 | Saturday | UCLA | 2.5 | UNLV |
| 2 | 2025-09-06 | Saturday | Alabama | 37.5 | Louisiana-Monroe |
| 2 | 2025-09-06 | Saturday | Virginia Tech | 1.5 | Vanderbilt |
| 2 | 2025-09-06 | Saturday | USC | 28.5 | Georgia Souther |
| 2 | 2025-09-06 | Saturday | Arizona State | 6.5 | Mississippi State |
| 2 | 2025-09-06 | Saturday | Oklahoma | 5.5 | Michigan |
| 2 | 2025-09-06 | Saturday | LSU | 37.5 | Louisiana Tech |